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Sulfates are the most important circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The principal oxidative metabolite is two-hydroxy ethinyl estradiol, shaped via the CYP3A4 isoform of cytochrome P450. Section of the first-move metabolism of ethinyl estradiol is thought to occur in gastrointestinal mucosa. Ethinyl es